Endocrine Abstracts

Aim: We aimed to examine whether there is any association between serum levels of 25-hydroxyvitamin D [25(OH)D3] and silent urinary tract infection (UTI) among postmenopausal women.Methods: Age, postmenopausal period, BMI, white blood cell count, serum C-reactive protein, calcium, phosphorus, alkaline phosphatase, parathormone, serum 25(OH)D3 levels and native urin speicemens were measured in 124 postmenopausal women without signs of UTI, on regular gyne...

Combined rapamycin-octreotide treatment has a stronger antiproliferative effect on non-functioning pituitary tumor cells compared with each drug alone. The mechanism of the combined treatment action was studied in AtT-20 pituitary tumor cells. Rapamycin is known to induce cell cycle arrest at the G1/S transition point. The entry of eukaryotic cells into the cell cycle is controlled primarily by the activation of cyclin-dependent kinases (CDK4/CDK6 and CDK2) by their respective...

Suppressive therapy with thyroxine is the standard conservative treatment for solitary benign thyroid nodules. However, factors which may influence the response to treatment remains controversal, as well as the risc of thyroxine administration.We prospectively evaluated the effects of twelve months thyroid-stimulating hormone suppression with Levothyroxine (L-T4) in reducing the volume of benign solitary nodules, and the effects of reduced...

The potential health threat posed by endocrine-disrupting chemicals has come to the forefront of environmental health in previous years and nowadays represents a major concern among scientific, regulatory and public communities. Different groups of environmental chemicals appear to have thyroid-disrupting properties. The lifelong exposure to these chemicals raises concerns about their deleterious effects on human health, having in mind that even subtle changes in the individua...

The lifelong exposure to mixtures of endocrine disrupting chemicals raises serious concerns about their deleterious effects on human health. Polychlorinated biphenyls (PCBs) had widespread use in numerous industrial applications, and were massively produced for several decades. After the discovery of the adverse effects of PCBs in the 1970s, brominated flame retardants (BFRs) were established as the major chemical flame retardant. Both chemicals persist in the environment and ...

Introduction: Central obesity is the source of inflammatory factors, causing endothelial dysfunction. In central nervous system, inflammatory factors mediate neurotransmitter metabolism promoting excitotoxicity and increase oxidative stress, and a major clinical symptom is depression. Mediterranean diet (MD) resulted as a good prevention method for depression.Aim: To examine the relationship of depression with abdominal obesity and metabolic syndrome (MS...

Background: Abdominal obesity, which in fact is a metabolic syndrome (MS), is related to decreased testosterone, insulin resistance (IR), increased inflammatory factors, non-alcoholic fat liver disease (NAFLD) and risk of early atherosclerosis. Elevated inflammatory markers (CRP) may interfere with insulin signal transduction at the neuronal level inducing hypogonadotropic hypogonadism.Objective: To examine testosterone relationship with abdominal obesit...

Objective: Obese PCOS have poor IVF outcomes. The aim of this study was to evaluate the impact of weight reduction with metformin alone or in adjunct with liraglutide on oocyte maturity and embryo quality in infertile obese PCOS population.Design/participants/main outcome measure: A 12-week prospective randomized study was conducted with 40 infertile PCOS (30.77±3.742 aged years, BMI 36.69±3.51 kg/m2, mean ± SD) who had been pre...

Thyrotoxic periodic paralysis (TPP) is uncommon complication of Graves’ disease mainly observed in young males of Asian origin. It is rarely seen among white hyperthyroid patients (0.1–0.2%), usually presented as lower extremities muscle weakness of sudden onset, probably cause by hypokalemia. Possible mechanism of hypokalemia is an increased sodium–potassium–adenosine triphosphatase pump activity with consequent massive shift og potassium from extracellula...

Ghrelin, the endogenous ligand of GH secretagogue receptor type 1a, has emerged as pleiotropic modulator of diverse biological functions, including energy homeostasis and recently, reproduction. The effects of i.c.v. administered ghrelin on morphological characteristics of pituitary FSH- and LH-cells were examined in adult male Wistar rats. The animals were randomized in two groups: control and experimental group, each consisted of seven animals, and implanted with an i.c.v. c...